Genomic diversity and divergence of SARS-CoV-2/COVID-19

RuntimeError: Failed to fetch
divergence = RuntimeError: Failed to fetch

Similarly, for a given point in time, is there evidence that viruses that are isolated during this time period are more genetically different from each other than at previous time points?

While there is no clear upward trend that might indicate that viral isolates are becoming increasingly dissimilar as time progresses.

diversity = RuntimeError: Failed to fetch

There are many factors that might contribute to changing genetic diversity in addition to viral evolution and dispersal.

  • the rate at which sequences are generated: more sequences from varied locations might increase diversity
  • where the sequences are sampled: if many sequences come from the same lab/loction, genetic diversity may be low
  • improved sequencing and bioinformatics: earlier sequences may appear more diverse because they had more sequencing errors

Data

date_format = ƒ(e)
divergence_data = TypeError: Failed to fetch
N_cutoff = 40
divergence_data_filtered = RuntimeError: Failed to fetch

Dependancies

d3 = Object {format: ƒ(t), formatPrefix: ƒ(t, n), timeFormat: ƒ(t), timeParse: ƒ(t), utcFormat: ƒ(t), utcParse: ƒ(t), Adder: class, Delaunay: class, FormatSpecifier: ƒ(t), InternMap: class, InternSet: class, Node: ƒ(t), Path: class, Voronoi: class, ZoomTransform: ƒ(t, n, e), active: ƒ(t, n), arc: ƒ(), area: ƒ(t, n, e), areaRadial: ƒ(), ascending: ƒ(t, n), …}
_ = ƒ(value)
vegalite = ƒ(…)

Source notebook: https://observablehq.com/@spond/current-state-of-sars-cov-2-evolution